In this paper, a general modelling framework employing a hybrid approach for modelling and simulation of reactive separation systems such as reactive distillation is presented. The general modelling framework allows rate-based as well as equilibrium-based models for steady state and dynamic simulation modes. The hybrid approach also provides tools for analysis of equilibrium for the rate-based model and for bifurcation analysis for all models. Simulation results validating the models and highlighting the hybrid approach are presented for two well-known reactive systems.