Inorganic Chemistry, Vol.40, No.2, 194-195, 2001
Model complexes of the active site in peptide deformylase: A new family of mononuclear N2S-M(II) complexes
A new tridentate N2Sthiolate ligand, PATH, has been prepared and includes a sterically hindered aliphatic thiolate donor as a cysteine mimic. PATH was employed in the synthesis of the monomeric complexes [(PATH)(MBr)-Br-[]] and [(PATH)(MNCS)-N-[]] (M = Zn, Co), which have been characterized by X-ray diffraction. These complexes are close structural analogues of the His(2)Cys site found in peptide deformylase.