We describe a novel concept for the preparation of desiccants based on polymeric blends. A hydrophilic channeling agent (e.g., PEG) is blended with a hydrophobic polymer (e.g., polypropylene) to produce interconnecting hydrophilic channels within the hydrophobic polymer. To make the system desiccating, a water-absorbing material is blended into the polymeric matrix to become distributed within the hydrophilic portion. The resultant blend may be molded and cast into plug-type inserts and liners for closed containers, or formed into films, sheets, beads, or pellets; its uses include pharmaceutical and industrial applications.