A physical map of the human genome

McPherson JD; Marra M; Hillier L; Waterston RH; Chinwalla A; Wallis J; Sekhon M; Wylie K; Mardis ER; Wilson RK; Fulton R; Kucaba TA; Wagner-McPherson C; Barbazuk WB; Gregory SG; Humphray SJ; French L; Evans RS; Bethel G; Whittaker A; Holden JL; McCann OT; Dunham A; Soderlund C; Scott CE; Bentley DR; Schuler G; Chen HC; Jang WH; Green ED; Idol JR; Maduro VVB; Montgomery KT; Lee E; Miller A; Emerling S; Kucherlapati R; Gibbs R; Scherer S; Gorrell JH; Sodergren E; Clerc-Blankenburg K; Tabor P; Naylor S; Garcia D; de Jong PJ; Catanese JJ; Nowak N; Osoegawa K; Qin SZ; Rowen L; Madan A; Dors M; Hood L; Trask B; Friedman C; Massa H; Cheung VG; Kirsch IR; Reid T; Yonescu R; Weissenbach J; Bruls T; Heilig R; Branscomb E; Olsen A; Doggett N; Cheng JF; Hawkins T; Myers RM; Shang J; Ramirez L; Schmutz J; Velasquez O; Dixon K; Stone NE; Cox DR; Haussler D; Kent WJ; Furey T; Rogic S; Kennedy S; Jones S; Rosenthal A; Wen GP; Schilhabel M; Gloeckner G; Nyakatura G; Siebert R; Schlegelberger B; Korenburg J; Chen XN; Fujiyama A; Hattori M; Toyoda A; Yada T; Park HS; Sakaki Y; Shimizu N; Asakawa S; Kawasaki K; Sasaki T; Shintani A; Shimizu A; Shibuya K; Kudoh J; Minoshima S; Ramser J; Seranski P; Hoff C; Poustka A; Reinhardt R; Lehrach H

Nature, Vol.409, No.6822, 934-941, 2001

McPherson JD, Marra M, Hillier L, Waterston RH, Chinwalla A, Wallis J, Sekhon M, Wylie K, Mardis ER, Wilson RK, Fulton R, Kucaba TA, Wagner-McPherson C, Barbazuk WB, Gregory SG, Humphray SJ, French L, Evans RS, Bethel G, Whittaker A, Holden JL, McCann OT, Dunham A, Soderlund C, Scott CE, Bentley DR, Schuler G, Chen HC, Jang WH, Green ED, Idol JR, Maduro VVB, Montgomery KT, Lee E, Miller A, Emerling S, Kucherlapati R, Gibbs R, Scherer S, Gorrell JH, Sodergren E, Clerc-Blankenburg K, Tabor P, Naylor S, Garcia D, de Jong PJ, Catanese JJ, Nowak N, Osoegawa K, Qin SZ, Rowen L, Madan A, Dors M, Hood L, Trask B, Friedman C, Massa H, Cheung VG, Kirsch IR, Reid T, Yonescu R, Weissenbach J, Bruls T, Heilig R, Branscomb E, Olsen A, Doggett N, Cheng JF, Hawkins T, Myers RM, Shang J, Ramirez L, Schmutz J, Velasquez O, Dixon K, Stone NE, Cox DR, Haussler D, Kent WJ, Furey T, Rogic S, Kennedy S, Jones S, Rosenthal A, Wen GP, Schilhabel M, Gloeckner G, Nyakatura G, Siebert R, Schlegelberger B, Korenburg J, Chen XN, Fujiyama A, Hattori M, Toyoda A, Yada T, Park HS, Sakaki Y, Shimizu N, Asakawa S, Kawasaki K, Sasaki T, Shintani A, Shimizu A, Shibuya K, Kudoh J, Minoshima S, Ramser J, Seranski P, Hoff C, Poustka A, Reinhardt R, Lehrach H

The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.