The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer-assisted transformations has been employed in the preparation of substituted 2-aminothiazole derivatives. 2-aminothiazoles were precipitated in parallel as hydrobromide monohydrate salts, directly redissolved, and reacted further using polymer-supported reagents to afford free-based 2-aminothiazoles, aminothiazoyloxamates, and aminothiazoylamides. (C) 2000 John Wiley & Sons, Inc.