Supercritical carbon dioxide is a preferred solvent substitute in the chemical process industries, but processing that requires contact between CO2 and an aqueous phase has been hindered by the inefficient phase contact and high capital cost of conventional contactors. We examine the phase-contact performance of an electrodispersion contactor in this service. We have dispersed droplets of aqueous phases into supercritical CO2 using pulsed, high-intensity electric fields. Using small-angle laser light scattering, we characterized the mean droplet size as a function of operating conditions (liquid flow rate, field strength, frequency, temperature, and pressure) and observed operating regions that yield submicron-sized droplets. The effects of temperature and pressure on droplet size were correlated with the interfacial tension. Then, using the extraction of ethanol from a water-ethanol solution as a test system, we attempted to characterized mass transfer performance, but under maximum CO2 flow rate conditions of the downstream liquid condensers, mass transfer was equilibrium-limited in all cases. Because of the small droplet size and high interfacial area, the electrodispersion contactor offers the potential for achieving excellent mass transfer performance. The submicron-sized droplets were efficiently coalesced electrostatically, and negligible entrainment was observed. We anticipate that initial commercial applications might arise in the processing of small volumes of high-value substances in aqueous media such as might be found, for instance, in the pharmaceutical industry.