Biotechnology Letters, Vol.16, No.10, 1065-1068, 1994
Effects of Polar Additives on the Enzyme Enantioselectivity of an Esterification Reaction in Organic-Solvents
The enantioselectivity of candida cylindracea lipase in esterification between ibuprofen and 1-butanol in organic solvents is influenced by adding a small amount of polar solvents. The results show that both the solvents and the amount added affected the reaction. Addition of 0.05 % ( v/v) N,N-dimethylformamide increase the ee value of the ester from 57.5 % of no addition to that of 91 %