A one-step integrated process for the generation of the high-octane fuel ether, diisopropyl ether (DIPE), from acetone-rich feedstocks has been demonstrated. Three continuous, downflow, reactor configurations have been considered, including a two-bed catalyst design separated by inerts, gradient multicatalyst combinations, and an integrated two-zone layout with differing catalyst compositions. The bifunctional catalysts have both hydrogenation and etherification/dehydration capabilities and may comprise groups IB, VIB, and VIII metals incorporated into acidic, large and medium-pore zeolites, groups III or IV metal oxides, as well as heteropoly acid structures. DIPE syntheses are typically conducted at 100-165 degrees C, under hydrogen pressure. The gradient reactor design, with careful choice of hydrogenation and etherification catalysts, allows DIPE to be generated in high selectivity and productivity.