This paper summarises the results of a 2-year study focusing on the development of a condition monitoring system for a fed-batch fermentation system operated by Biochemie Ltd. in Austria. Consumer pressure has resulted in a greater emphasis in industry on product quality. As a direct consequence, the importance of accurate process monitoring has increased steadily in recent years. This paper demonstrates the application of multivariate statistical routines to provide process operators with a monitoring tool capable of detecting process abnormalities.