Metarhizium anisopliae was grown by solid-state fermentation on a series of compositions of rice, rice bran, or rice husk media for the production of cyclodepsipeptides, destruxins A and B. The best yield for destruxin A and destruxin B were 2.9 mg kg(-1) substrate and 227 mg kg(-1) substrate, respectively, after 14 days cultivation with rice/bran/husk medium at 71% water content together with water activity of 0.921.