High temperature plastic deformation in a single crystal of a 2-3-4 garnet, Ca3Ga2Ge3O12, was investigated. A Czochralski-grown single crystal of Ca3Ga2Ge3O12 was deformed in compression in air along (100) or (110) at temperatures of 1472 to 1573 K (T/T-m = 0.90-0.96). The samples show higher resistance to creep than other 3-3 garnets, namely the flow stress at the strain-rate of 4 x 10(-6) s(-1) is similar to 200-400 MPa in this temperature range. The TEM observations of dislocation microstructures show little evidence of climb and plastic deformation in this garnet appears to occur exclusively by dislocation glide, using mostly the 1/2 (111){110} slip systems. Dislocations with b = (100) are frequently observed but they are interpreted as products of dislocation reactions among 1/2 (111). The single crystal used contained a number of precipitates that grew during annealing and also during deformation. These precipitates act as sources for dislocations but no evidence for their significant effects on creep strength is observed. The normalized flow law of Ca3Ga2Ge3O12 is similar to other 3-3 oxide garnets (e.g., YAG, GGG), but in contrast to 3-3 garnets, the more stable and hence less mobile dislocations have a large edge component.