New formulations of plastisols based on low-toxicity plasticizers were proposed and characterized. Traditional phthalate plasticizers were replaced in the plastisols studied in this research by polymeric plasticizers (i.e., saturated polyesters), produced by the reaction of a diol and a carboxylic acid. The main drawback for the use of these plasticizers in formulations of PVC plastisols is a significant increase of the paste viscosity, which decreases their processability; thus, the use of additional additives to reduce viscosity is recommended. This study also includes the optimization of the processing conditions (cure temperature and time) of the proposed plastisols: complete cure was obtained at 140 degreesC and 10 min. It is reported that the final properties of plastisols are very sensitive with respect to the processing conditions; in fact, insufficient plasticization or degradation can affect the material when processed out of the optimum conditions. The influence of the plasticizer concentration on mechanical and optical properties, such as tensile strength, hardness, brightness, and the like, is also reported. In summary, the proposed plastisols, with low-toxicity plasticizers, offer a valid alternative to traditional PVC plastisols based on phthalate plasticizers.