The inclusion compound (IC) between the FDA-approved antibacterial Irgasan DP300 (Trichlosan), and beta -cyclodextrin (CD) has been formed. When the Irgasan-beta -CD-IC is embedded in biodegradeable/bioabsorbable films Of poly(epsilon -caprolactone) (PCL) at low levels (a few wt %), they are rendered resistant to the growth of E. coli bacteria. When these same PCL films embedded with Irgasan-beta -CD-IC are used as the adhesive for laminating cotton fabrics, we observe the resulting cotton laminates to also be resistant to the growth of E. coli bacteria. These results hold promise for the fabrication of bacteria-resistant polymer films and fibers, as well as antibacterial fabrics, by means of simple melt processing with Irgasan-beta -CD-IC.