AIChE Journal, Vol.47, No.6, 1432-1437, 2001
Verification of scaling laws for degrading PLA-b-PEG-b-PLA hydrogels
Several macroscopic proper-ties of degrading poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PLA-b-PEG-b-PLA) hydrogels were compared to one another as functions of degradation time. The specific hydrogel properties measured were the compressive modulus (K), the volumetric swelling ratio ((Q) under tilde), and the normalized compressive modulus (K-NORM = K (Q) under tilde (1/3)). Their comparisons were used to evaluate the application ability of fundamental thermodynamic theories developed for nondegradable hydrogels on a degradable system. The equations predict scaling factors of -2, -5/3, and 6/5 for the dependence of K on (Q) under tilde, K-NORM on (Q) under tilde, and K on K-NORM respectively. These important experimental data for a degrading hydrogel system initially show goon agreement with the scaling predictions. Further examination, however; reveals the scaling factors to change over the course of the degradation process. These changes are attributed at least in part, to the changing chemical mechanical, and ionic properties of the degrading copolymer networks.