New degradable poly(ether-anhydride) networks were synthesized by UV photopolymerization. Dicarboxylated poly(ethylene glycol) (PEG) or poly(tetramethylene glycol) (PTMG) was reacted with an excess of methacrylic anhydride to form dimethacrylated macromers containing anhydride linkages. The percent of conversion for the macromer formation was more than 80% at 60 degrees C after 24 h. H-1 NMR and IR spectroscopies show the presence of anhydride linkages in the macromer. In vitro degradation studies were carried out at 37 degrees C in PBS with crosslinked polymer networks formed by UV irradiation. All PEG-based polymers degraded within 2 days, while PTMG-based polymers degraded by 50% of the initial weight after 14 days.