An experimental apparatus was used to measure the solubility of ethyl nitrite in mixed solvents under the lower pressure and higher temperature. The solubilities of ethyl nitrite in mixed solvents of ethanol-water at 15 degrees C-40 degrees C and ethanol-diethyl oxalate at 20 degrees C-40 degrees C were determined. A Henry constant model has been improved, and the interaction parameters have been fitted from experimental data. The calculation results have been compared with experimental data; the results obtained are satisfactory.