Principal component analysis (PCA) has been used successfully as a multivariate statistical process control (MSPC) tool for detecting faults in processes with highly correlated variables. In the present work, a novel statistical process monitoring method is proposed for further improvement of monitoring performance. It is termed 'moving principal component analysis' (MPCA) because PCA is applied on-line by moving the time-window. In MPCA, changes in the direction of each principal component or changes in the subspace spanned by several principal components are monitored. In other words, changes in the correlation structure of process variables, instead of changes in the scores of predefined principal components, are monitored by using MPCA. The monitoring performance of the proposed method and that of the conventional MSPC method are compared with application to simulated data obtained from a simple 2 x 2 process and the Tennessee Eastman process. The results clearly show that the monitoring performance of MPCA is considerably better than that of the conventional MSPC method and that dynamic monitoring is superior to static monitoring,