Synthesis and Properties of Multiblock Copolymers Consisting of Oligo(L-lactic acid) and Poly(oxyethylene-co-oxypropylene) with Different Composition

Chan Woo Lee

Korea Polymer Journal, Vol.9, No.5, 259-266, October, 2001

Chan Woo Lee^†

Department of Innovative Industrial Technology, Hoseo University, Asan-City 336-795, Korea

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Multiblock copolymer was synthesized by the copolycondensation of oligo(L-lactic acid) prepared by thermal dehydration of L-lactic acid, Pluronic™(PN) and dodecanedioic acid as carboxyl/hydroxyl adjusting agent. This polycondensation proceeded by catalysis of stannous oxide to give the multiblock copolymers with high molecular weight and wide range of compositions. Polymer film was prepared by casting the chloroform solution of the multiblock copolymers having different composition. The multiblock copolymers having relatively high contents of poly(L-lactide) were melt spun into filaments which were subsequently drawn at 60 ℃. The copolymer films and the filaments showed an improved flexibility due to the incorporation of the soft segments.

[References]

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Iwa T, Hirano M, Yamashita R, Sakatoku M, Chem. Abstr., 101, 43491g (1984)
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Eling B, Gogolewski S, Penning AJ, Polymer, 23, 1587 (1982)
Jamshidi K, Hyon SH, Nakamura T, Ikada Y, Shimizu Y, Teramatsu T, in Biological and Biomechanical Performance of Biomaterials, P. Christel, A. Meunier, and A.J.C. Lee, Eds., Elsevier, Amsterdam, 1986, pp 227 (1986)
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Vitalis EA, Chem. Abstr., 54, 7173d (1960)
Kitao T, Kimura Y, Ohtani N, Matsuzaki Y, Yabuuchi K, Jpn. Kokai Tokyo Koho Japan Patent, 211504 (1986)
Lee CW, Kang YG, Jun K, Korea Polym. J., 9(2), 84 (2001)
Vittaz M, Bazile D, Spenlehauer G, Verrecchia T, Veillard M, Puisieux F, Labarre D, Biomaterials, 17, 1575 (1996)
Park TG, Cohen S, Langer R, Macromolecules, 25, 116 (1992)
Lee CW, Kimura Y, Bull. Chem. Soc. Jpn., 69, 1787 (1996)
Chen XH, Mccarthy SP, Gross RA, Macromolecules, 30(15), 4295 (1997)
Vitalis EA, (Am. Cyanamid Co.), U.S. Patent, 2,917,410 (1959)

[Referenced By]

[Related Articles]

[1] Frazza EJ, Schmitt EE, Mater. Res. Symp., 1, 43 (1971)

[2] Gilding DK, Reed AM, Polymer, 20, 1459 (1979)

[3] Gogolewski S, Pennings AJ, Makromol. Chem. Rapid Commun., 4, 213 (1983)

[4] Fredericks RJ, Melveger AJ, Dolegiewitz J, J. Polym. Sci. B: Polym. Phys., 22, 57 (1984)

[5] Alexander H, Parsons JR, Strauchler ID, Corcoran SF, Gona O, Mayott C, Weis AB, Orthop. Rev., 10, 41 (1981)

[6] Echeverria E, Jimenez J, Surgery, 131, 1 (1970)

[7] Sander HJ, Chem. Eng. News, 31, 67 (1985)

[8] Okada H, Ogawa Y, Yashiki K, Chem. Abstr., (Takeda Chem. Ind), Jpn. Kokai Tokyo Koho JP 60-100516, 1985; Chem. Abstr., 103, 166162z (1985)

[9] Iwa T, Hirano M, Yamashita R, Sakatoku M, Igaku Ayumi, 128, 655 (1984)

[10] Iwa T, Hirano M, Yamashita R, Sakatoku M, Chem. Abstr., 101, 43491g (1984)

[11] Dardik H, Dardik I, Laufman H, Am. J. Surg., 121, 656 (1971)

[12] Eling B, Gogolewski S, Penning AJ, Polymer, 23, 1587 (1982)

[13] Jamshidi K, Hyon SH, Nakamura T, Ikada Y, Shimizu Y, Teramatsu T, in Biological and Biomechanical Performance of Biomaterials, P. Christel, A. Meunier, and A.J.C. Lee, Eds., Elsevier, Amsterdam, 1986, pp 227 (1986)

[14] Kalb B, Penning AJ, Polymer, 21, 607 (1980)

[15] Chu CC, in Biomaterials, G.D. Winter, D.F. Gibbons, and H. Plenk, Jr., Eds., John Wiley, New York, pp 781 (1982)

[16] Miller RA, Brady JM, Cutright DE, J. Biomed. Mater. Res., 11, 711 (1977)

[17] Reed AM, Gilding DK, Polymer, 22, 499 (1981)

[18] Gallot BRM, Advances in Polymer Science, 29, Structure and Properties of Polymers, Springer Verlag, Heidelberg, FRG, pp 85 (1978)

[19] Casey DJ, Huffman KR, (Am. Cyanamid Co.) U.S. Patent, 4,438,253 (1984)

[20] Vitalis EA, Chem. Abstr., 54, 7173d (1960)

[21] Kitao T, Kimura Y, Ohtani N, Matsuzaki Y, Yabuuchi K, Jpn. Kokai Tokyo Koho Japan Patent, 211504 (1986)

[22] Lee CW, Kang YG, Jun K, Korea Polym. J., 9(2), 84 (2001)

[23] Vittaz M, Bazile D, Spenlehauer G, Verrecchia T, Veillard M, Puisieux F, Labarre D, Biomaterials, 17, 1575 (1996)

[24] Park TG, Cohen S, Langer R, Macromolecules, 25, 116 (1992)

[25] Lee CW, Kimura Y, Bull. Chem. Soc. Jpn., 69, 1787 (1996)

[26] Chen XH, Mccarthy SP, Gross RA, Macromolecules, 30(15), 4295 (1997)

[27] Vitalis EA, (Am. Cyanamid Co.), U.S. Patent, 2,917,410 (1959)