화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.12, No.7, 718-723, November, 2001
Export Citation
방사선 가교에 의한 젤라틴 하이드로겔과 PVP/젤라틴 하이드로겔의 제조 및 상처 치료용 드레싱으로의 이용
Preparation and Its Application for Wound Dressing of Gelatin Hydrogel and PVP/Gelatin Hydrogel by Radiation Crosslinking
박경란, 김동표, 노영창1, †
  • 충남대학교 대학원 공업화학과, 대전 305-764
  • 1한국원자력연구소 동위원소/방사선 응용연구팀, 대전 305-600
Kyoung Ran Park, Dong Pyo Kim, and Young Chang Nho1, †
  • Department of Industrial Chemistry, Graduate School, Chungnam National University, Taejon 305-764, Korea
  • 1Radioisotopes Radiation Applicaton Team, Korea Atomic Energy Research Institute, Taejon 305-600, Korea
E-mail:
초록
본 연구에서는, 방사선((60)Co γ-rays) 가교를 이용하여 젤라틴과 poly(N-vinylpyrrolidone)(PVP)의 혼합물로부터 하이드로겔(hydrogels)을 제조하였다. 하이드로겔이 상처 치료용 드레싱으로 사용될 수 있는지 예측하기 위해 겔화율, 팽윤도, 겔강도 같은 기계적 성질을 측정하였다. 젤라틴 용액의 농도는 5 ~ 20 wt%이었다. PVP와 젤라틴의 비는 100 : 0 ~ 0 : 100 이고, 이 PVP/젤라틴 용액의 고형분 농도는 20 wt%이었다. 하이드로겔의 기계적 성질에 조사선량이 미치는 영향을 예측하기 위해 젤라틴 또는 PVP/젤라틴 혼합물에 25, 35, 50, 60, 70 kGy의 감마선을 조사하였다. 겔화율은 젤라틴이 감소할수록 증가하였고, 조사선량이 커질수록 증가하였다. 팽윤도는 젤라틴이 증가할수록 증가하고, 조사선량이 작을수록 증가하였다. 팽윤도는 겔화가 증가할수록 가교 밀도가 증가하기 때문에 겔화율에 반비례한다. 겔강도는 조사선량이 증가할수록 커졌다. 두 하이드로겔이 상업용 바셀린 거즈보다 치료 효과가 우수하였다.
In this study, hydrogels from a mixture of gelatin and poly(N-vinylpyrrolidone)(PVP) were made by γ-ray irradiation. The mechanical properties of gelation, water absorptivity, and gel strength were examined to evaluate the hydrogels for wound dressing. The concentration of gelatin solutions was in the range of 5 ~ 20 wt%. The PVP to gelatin ratio was allowed to vary from 100 to 0 and 0 to 100. The solid concentration of PVP/gelatin solution was 20 wt%. Gamma irradiation doses of 25, 35, 50, 60, and 70 kGy, respectively, were exposed to a mixture of gelatin or PVP/ gelatin to evaluate the effect of irradiation dose on the mechanical properties of hydrogels. The results showed that gel content was increased as gelatin concentration in gelatin or PVP/gelatin decreased, or as irradiation dose increased. Swelling percent was increased as gelatin concentration in gelatin or PVP/gelatin increased, or as irradiation dose decreased. The swelling percent was inversely proportional to the gel percent because crosslinking density increased with increasing gelatin. Gel strength was increased in proportional to the irradiation dose. This study showed the hydrogel dressing had a better curing effect than common vaseline gauze.
Keywords:hydrogels;radiation;gelatin;PVP
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