Fourier Transform-Ion Cyclotron Resonance (FT-ICR) mass spectrometric studies of both cationic water clusters H+(H2O)(n), n = 1-70, and anionic water clusters X-(H2O)(n), n 1-30, X = OH, O, with acetone and acetaldehyde are reported. For the cations a sequence of ligand exchange and fragmentation reactions results in "solvated proton" complex ion final products. In the anionic OH-(H2O)(n) clusters, on the other hand, an OH- catalyzed aldol addition of the carbonyl compounds with a true covalent bond formation is observed. The anionic and cationic water clusters thus behave similar to basic and acidic aqueous solutions.