In an open material system where the residence time distribution of a fluid is known, it is possible, using micromixing Zwietering’ model to predict the results of linear interaction between the fluid and the wall of system but also for the aerosol particles transported by the fluid flow. This methodology is applied for aerosol deposition by thermophoresis in cylindrical pipe with constant wall temperature. The interpretation of experimental results in laminar flow shows that, for Knudsen numbers between 0.2 and 1.0, the thermophoresis coefficient must be calculated by Talbot’ correlation. Finally, in transition flow, the aerosol mass deposition by thermophoresis and turbulent diffusion becomes probably minimal.