리파제를 이용한 모노글리세리드의 선택적 합성 방법에 관한 연구

정대원; 송재현; Dae won Chung; Jhea hyun Song

Journal of the Korean Industrial and Engineering Chemistry, Vol.12, No.8, 937-940, December, 2001

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리파제를 이용한 모노글리세리드의 선택적 합성 방법에 관한 연구

A Studty on the Method for Selective Synthesis of Monoglyceride using Lipase

정대원 ^†, 송재현

수원대학교 공과대학 고분자공학과, 수원 400-600

Dae won Chung^†, and Jhea hyun Song

Department of Polymer Engineering, College of Engineering, Suwon University, Suwon 400-600, Korea

E-mail:

초록

본 연구에서는 식품첨가제 용도의 계면활성제로서 널리 사용되고 있는 모노글리세리드(MG)를 리파제 존재 하에서 선택적으로 합성하였다. 기존의 방법과는 달리 글리세롤과 메틸스테아레이트의 에스테르 교환반응을 유기용매 중에서 수행함으로써 디글리세리드의 생성을 1% 이하로 억제하면서 60% 이상의 전환율로 MG를 합성할 수 있었다. 본 논문에서는 반응 물질의 몰비 또는 유기용매를 변화시키면서 그에 따른 반응성 및 반응 선택성에 미치는 영향에 관하여 연구하였다.

Monoglyceride (MG), which is one of the major surfactants used in food-additive applications, was synthesized using lipase. Transesterification of glycerol (G) and methyl stearate (MS) in organic solvent resulted in more than 60% conversion to MG, whereas the formation of diglyceride was kept at less than 1%. In the paper, the effect of mole ratios of reagents and solvent on the reactivity and the selectivity was investigated.

Keywords:monoglyceride;lipase;transesterification;glycerol;methyl stearate

[References]

Porter MR, "Handbook of Surfactants," 2nd Ed. Blackie Academic & Profession (1994)
Garcia-Alles LF, Gotor V, Biotechnol. Bioeng., 59(6), 684 (1998)
Gandhi NN, Patil NS, Sawant SB, Joshi JB, Wangikar PP, Mukesh D, Catal. Rev.-Sci. Eng., 42(4), 439 (2000)
McNeil GP, Shimizu S, Yamane T, J. Am. Oil Chem. Soc., 68 (1991)
McNeil GP, Yamane T, J. Am. Oil Chem. Soc., 68(6) (1991)
Yamane T, European Patent, 445,692 (1992)
Ferreira S, Fonseca MMR, Bioprocess Eng., 12, 327 (1995)
Zaks A, Gross A, U.S. Patent, 5,316,927 (1992)
Akoh CC, Cooper C, Nwosu CV, J. Am. Oil Chem. Soc., 69, 257 (1992)
Hayes DG, Gulari E, Biotechnol. Bioeng., 38, 507 (1991)
Berger M, Schneider MP, J. Am. Oil Chem. Soc., 69, 961 (1992)
Holmberg K, Osterberg E, J. Am. Oil Chem. Soc., 65, 1544 (1988)
Brandrup J, Immergut EH, "Handbook of Polymer," 3rd Ed. (1989)

[Referenced By]

[Related Articles]

[1] Porter MR, "Handbook of Surfactants," 2nd Ed. Blackie Academic & Profession (1994)

[2] Garcia-Alles LF, Gotor V, Biotechnol. Bioeng., 59(6), 684 (1998)

[3] Gandhi NN, Patil NS, Sawant SB, Joshi JB, Wangikar PP, Mukesh D, Catal. Rev.-Sci. Eng., 42(4), 439 (2000)

[4] McNeil GP, Shimizu S, Yamane T, J. Am. Oil Chem. Soc., 68 (1991)

[5] McNeil GP, Yamane T, J. Am. Oil Chem. Soc., 68(6) (1991)

[6] Yamane T, European Patent, 445,692 (1992)

[7] Ferreira S, Fonseca MMR, Bioprocess Eng., 12, 327 (1995)

[8] Zaks A, Gross A, U.S. Patent, 5,316,927 (1992)

[9] Akoh CC, Cooper C, Nwosu CV, J. Am. Oil Chem. Soc., 69, 257 (1992)

[10] Hayes DG, Gulari E, Biotechnol. Bioeng., 38, 507 (1991)

[11] Berger M, Schneider MP, J. Am. Oil Chem. Soc., 69, 961 (1992)

[12] Holmberg K, Osterberg E, J. Am. Oil Chem. Soc., 65, 1544 (1988)

[13] Brandrup J, Immergut EH, "Handbook of Polymer," 3rd Ed. (1989)