Based on the analysis of the principles of heat and mass transfer from the liquid bulk to bubble surface during nucleation, a new theoretical method to predict the heat transfer of the nucleate pool boiling in binary mixtures is proposed in this paper by using the heat and mass transfer analogy (Colburn analogy) at the bubble surface transfer layers. With use of Theme＇s concept of boiling range, an approximate method is derived to realize the calculation. The predicted results by this method are in good agreement with the experimental data from different sources. This hypothesis can also be applied to electrolyte solutions. This method is restricted to developed boiling cases, fortunately, which occur in most industrial applications.