Langmuir, Vol.17, No.19, 5971-5977, 2001
Meniscus force nanografting: Nanoscopic patterning of DNA
Thiol-modified DNA is patterned with an atomic force microscope (AFM) on a resist-covered gold surface with line widths as small as 15 nm at speeds as high as 320 mum/s. In meniscus force nanografting, a drop of patterning solution simultaneously wets a hydrophilic resist on gold and an AFM tip. The surface tension supplies enough normal force for the tip to selectively remove the resist molecules and allow the DNA to attach to the gold surface. Different DNA-derivatized nanostructures can then hybridize to the complementary, surface-bound DNA in a demonstration of surface initiated orthogonal self-assembly.