Titanium silicate ETS-10 was found to be a suitable support for metal catalysts, having high surface area, high ion-exchange capability and no acidic functions. In this paper, the M-ETS-10 commercial form (where M stands for Na and K) was first exchanged with Co and thus tested in CO hydrogenation (Fischer-Tropsch synthesis). Moreover, the sample was also doped with small amounts of ruthenium to improve the Co reducibility. The successive catalytic tests revealed a strong increase in the CO conversion and a modification in the selectivity of the hydrocarbon fractions.