The kinetics of benzene alkylation with isopropyl alcohol has been studied in the vapor phase over the H form of Beta zeolite as the catalyst. On the basis of the product distribution pattern obtained over this large-pore zeolite, a reaction mechanism has been proposed. From this reaction network, a simple stoichiometric model has been derived and fitted to the kinetic data. The deactivation kinetics has also been investigated in a selected low-temperature range. The activation energies of all reactions in the network have been determined. The activation energy for the deactivation reaction in the chosen temperature range is found to be lower than that for the main reaction.