Euler/Euler CFD simulations are validated against experimental data acquired in a 2D rectangular column with 2 mm gap thickness. Data was collected using image velocimetry and laser velocimetry techniques, from bubbly to slug flow regimes, including the two hydrodynamic situations of stagnant and flowing liquid. Experimental data profiling was carried out at different axial locations providing a suitable database for CFD modelling. Two-phase flow was simulated by the commercial CFD package CFX 4.2 taking into account the drag force term obtained experimentally and using the lift force based on the Bernoulli effect, as proposed by Ranade (Trans. Inst. Chem. Eng. 75 (1997) 14). Turbulence was modelled by an extra transport equation for bubble-induced turbulence, that allows for the inclusion of experimentally verified anisotropic effects, as proposed by Lopez de Bertodano, Lahey, and Jones (Int. J. Multiphase Flow 20 (1994) 805).