The dilution enthalpies of L-alanine and L-serine in various aqueous glucose solutions have been determined using LKB-2277 flow microcalorimetry at 298.15 K. The homogeneous enthalpic interaction coefficients over the whole range of aqueous glucose solutions have been calculated according to the excess enthalpy concept. The results were interpreted from the point of view of solute-solute interactions involved by solvent effects.