Planar Bilayer Lipid Membrane (BLM) was used as a model of liposome drug delivery system. By establishing the relations between membrane electrical properties and liposome characters, the behavior of liposomes in various conditions can be predicted by means of measuring, sensitive electrical proper-ties of BLM. When different ratios of cholesterol incorporated into membranes, or various quantities of detergents added into solutions, membrane resistance (Rm) and capacitance (Cm) changed regularly. Results indicated that there exited obvious relations between membrane electrical properties and characters of liposomes, thus BLM can become a useful and simple method to study liposome drug delivery system.