Photoswitchable redox-activated monolayers on electrode supports act as molecular electronic systems for the electronic transduction of recorded photonic information. Photoisomerizable monolayers assembled on electrodes may act as command interfaces far controlling interfacial electron transfer and thus act as interfaces for the amperometric transduction of photonic signals recorded by the monolayer. Photoswitchable biomaterials assembled on electronic transducers represent novel optobioelectronic systems. This is exemplified by the organization of a photoswitchable enzyme for the amplified amperometric transduction of photonic signals, and by the tailoring of reversible immunosensor systems.