Palladium clusters were synthesized by reduction of palladium( II) acetate in the presence of a bipyridyl ligand (1) with an initiator for polymerization of 2-methyl-2-oxazoline. The 1-protected palladium clusters were soluble in CHCl3 and CH2Cl2. The 1-protected palladium clusters were combined with 2-methyl-2-oxazoline in chloroform. After polymerization, the reacted bipyridyl ligand was removed from the palladium cluster by suspending the obtained palladium clusters with pyridine. The H-1 NMR measurement indicated that the reacted bipyridyl ligand was formed via surface polymerization of 2-methyl-2-oxazoline.