As part of the preparations for waste disposal from the Julich Experimental Nuclear Power Plant high-temperature reactor, an analysis system was developed at the Institute for Safety Research and Reactor Technology of Forschungszentrum Julich GmbH with the aim of identifying and quantifying 47 nuclides from both metallic and ceramic materials. In addition to the conventional wet-chemical separation schemes, high-performance liquid chromatography was used on an analytical scale for the determination of most beta -emitters and of those nuclides that decay via electron capture. The associated advantages and drawbacks, as well as the problems encountered and their solutions, are explained with the aid of selected chromatograms.