Sustainability would never be achieved farewell as agricultural practices continue beyond the carrying capacity of the ecosystem through the exaggerated abuse of agricultural chemicals. The rapid growth of agricultural productivity in chemical farming systems is shrinking off. Moreover, environmental torrent from agricultural activities jeopardizes agricultural growth in several countries. Problems associated with the wealthy agricultural production in the developed world and underproduction in developing countries necessitate a widely accepted assessment of the present status of agriculture. It is time to install new farming systems committed to following environmental and sustainable approaches, and producing healthy food free from agrochemical residues. Ecologically oriented farming routines are being developed within the frame of the recent achievements in environmental biotechnology, the mos. important of which is the clean farming system which is increasingly acknowledged as a potential solution to copious problems overlaying present world agriculture. It is a farming system, which aims at evading the routine use of agricultural chemicals and reducing their rates of application. Clean farming systems directly give rise to four environmental biotechnologies, i.e.. recycling of composted organic waste, fortifying the rhizosphere soil with biofertilizers, encouraging the use of biopesticides in agricultural practices and bioremediation of polluted agro-ecosystems.