Chromatography is a separation method which produces product solutions of high purity, but often also with a high product dilution. In this study, feasible strategies for downstream processing of typical chromatographic product solutions were developed theoretically. The unit operations membrane processes, precipitation, crystallization, and evaporation, proved to be the most suitable for the treatment of chromatographic product solutions. Computer models of these unit operations were made to simulate the chosen refining strategies. The results of the process simulation for the drug intermediate product EMD 53986 (5-(1,2,3,4-tetrahydroquinoline-6-yl)-6-methyl-3,6-dihydro-1,3,4-thiadiazine-2-one) are given to exemplify the quality of the data process simulation can supply for process planning and for equipment design. An overview is given. The specific demands of small drug molecules are pointed out by describing the contrary proceedings of the other groups of molecular compounds like small and larger biologically active compounds. For many chromatographic separations, different continuous and discontinuous chromatography methods are available. In this study, the efficiency of common batchwise chromatography and continuous simulated-moving-bed (SMB) chromatography were compared by the, respectively, required refining steps for isolating the product from the chromatographic product solution.