The methane oxidation by oxygen is carried out on catalytic systems Mo-V-Cu-P-O, W-Pb-B-O and V-Zn-Bi-B-O containing 1% Pt or Pd. The design of reactor makes possible to decrease the deep oxidation rate and leads to increase of oxygenates yield. Thermodynamic analysis of methane and sulphur interaction with calculation of all product concentrations at molar relationship S-2:CH4 from 0 to 5, temperatures in the range from 750 to 1500 K and pressures from 1 to 100 atm has been carried out. The possibility of interaction between methane and sulphur forming products of partial oxidation and condensation was confirmed experimentally.