In this paper, we will propose a self-tuning method for a class of nonlinear PID control systems based on Lyapunov approach. The three PID control gains are adjustable parameters and will be updated online with a stable adaptation mechanism such that the PID control law tracks certain feedback linearization control, which is previously designed. The stability of closed-loop nonlinear PID control system is analyzed and guaranteed by introducing a supervisory control and a modified adaptation law with projection. Finally, a tracking control of an inverted pendulum system is illustrated to demonstrate the control performance by using the proposed method,