A novel salting-out extraction process has been developed to separate isopropanol from aqueous solution. Potassium carbonate was experimentally shown to be effective in modifying the liquid-liquid equilibrium (LLE) of an isopropanol/water/hexane system in favour of the solvent extraction of isopropanol from an aqueous solution with hexane, particularly at suitable salt concentrations. Potassium carbonate enlarged the area of the two-phase region. This effect essentially increased the distribution coefficient of isopropanol between hexane and water and increased the separation factor for isopropanol vs water, which is an important consideration in designing a solvent extraction process. The effects of potassium carbonate concentration, temperature and pH on the LLE were studied. Finally, a phi 30mm x 1200mm reciprocating plate column (RPC) was tested to separate isopropanol from an aqueous solution. When isopropanol in an aqueous solution with composition of isopropanol/water=1:0.95 (wt/wt) was extracted by hexane assisted with 30% (wt%) potassium carbonate aqueous solution, the alcohol-water ratio increased to 11:1 in the extract.