Synthesis and Characterization of Poly(alkyl α , L-glutamate-co-ethylene oxide)

Gunwoo Kim; Jin-Yeol Kim; Daewon Sohn; Youngil Lee

Macromolecular Research, Vol.10, No.1, 49-52, February, 2002

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Synthesis and Characterization of Poly(alkyl α , L-glutamate-co-ethylene oxide)

Gunwoo Kim, Jin-Yeol Kim, Daewon Sohn^†, and Youngil Lee¹

Department of Chemistry, Hanyang University, 17 Haengdang Dong, Seoul 133-791, Korea
¹Dongbu Advanced Research Center, Taejon 305-380, Korea

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Rod-coil amphiphilic block copolymers, PALG-PEOs, poly(alkyl α, L-glutamate-co-ethylene oxide)s, were successfully synthesized in three steps: 1) esterification of L-glutamic acid, 2) synthesis of γ-alkyl L-gultamate N-carboxyanhydride, and 3) polymerization of NCA monomers. These molecules form polymeric micelles with the hydrophobic core and hydrophilic corona in aqueous solution, which were characterized by light scattering and static fluorescence measurement.

Keywords:polyglutamate;PEO;NCA;rod-coil;polymer micelle;light scattering

[References]

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[1] Duda G, Wegner G, Makromol. Chem. Rapid Commun., 9, 495 (1988)

[2] Schwarz DK, Viswanathan R, Zasadzinski JA, Science, 257, 508 (1992)

[3] Lee S, Dutcher JR, Stegeman GI, Duda G, Wegner G, Knoll W, Phys. Rev. Lett., 70, 2427 (1993)

[4] Block H, Poly(γ-benzyl-L-glutamate) and Other Glutamic Acid Containing Polymers, Gordon and Breach Science Publishers, New York (1983)

[5] Poche DS, Daly WH, Russo PS, Macromolecules, 28(20), 6745 (1995)

[6] Dessipri E, Tirrell DA, Atkins ED, Macromolecules, 29(10), 3545 (1996)

[7] Cho CS, Nah JW, Jeong YI, Cheon JB, Asayama S, Ise H, Akaike T, Polymer, 40(24), 6769 (1999)

[8] Fong B, Russo PS, Langmuir, 15(13), 4421 (1999)

[9] Wassermann D, Garber G, U.S. Patent, 3,285,953 (1996)

[10] Wang Y, Winnik MA, Langmuir, 6, 1437 (1990)

[11] Kalyanasundaram K, Thomas JK, J. Am. Chem. Soc., 99, 2039 (1997)

[12] Thomas JK, Chem. Rev., 80, 283 (1980)