The Computational Simulation of Skin-Permeation of Vitamins C and E

Whi Dong Joung; Sung Chul Yi

Journal of Industrial and Engineering Chemistry, Vol.8, No.2, 191-195, March, 2002

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The Computational Simulation of Skin-Permeation of Vitamins C and E

Whi Dong Joung, and Sung Chul Yi^†

Department of Chemical Engineering, CPRC, Hanyang University, 17 Haegdangdong Sungdonggu, Seoul 133-791, Korea

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An advanced two-dimensional bilayer skin bioconversion model is developed to assay the skin-permeation of vitamins C and E. The numerical method of line (NMOL) is exploited to solve a set of governing equations based on species mass balance. The penetration profiles of vitamins C and E in the stratum corneum decrease quickly along the depth of the stratum corneum. But the penetration profile of vitamin C is more uniform than that of vitamin E along the depth of the viable skin. This result shows that a large amount of vitamin E is bio-converted by the enzyme in the viable skin. The first order kinetics of vitamins C and E bioconversion in the viable skin is assumed as the exponential decay law due to skin aging. The developed model is useful when evaluating skin penetration of vitamins C and E, not only to predict the penetration profiles but also to examine how much enzyme in the viable skin affects skin-penetration of vitamins C and E.

Keywords:skin permeation;vitamin C;vitamin E;bilayer-bioconversion model

[References]

Lee ARC, Tojo K, Chem. Pharm. Bull., 46, 174 (1998)
Tojo K, Lee ARC, J. Soc. Cosmet. Chem., 38, 333 (1987)
Kammerau B, Zesch A, Stuttgen G, J. Invest. Derm., 64, 145 (1975)
Schaefer H, Zesch A, Stuttgen G, Arch. Derm. Res., 258, 241 (1977)
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Kakemi K, Kameda H, Ueda M, Koizumi T, Chem. Pharm. Bull., 23, 2109 (1975)
Tojo K, Chem. Eng. Jpn., 20, 300 (1987)
Tojo K, Lee ARC, J. Soc. Cosmet. Chem., 40, 119 (1989)
Manitz R, Lucht W, Strehmel K, Weiner R, Neubert R, J. Pharm. Sci., 87, 873 (1998)
Brown PN, Byrne GD, Hindmarsh AC, J. Sci. Stat. Comput., SIAM, 10, 1038 (1989)
Choi JW, Cho KS, Oh BK, Youn IJ, Jeong J, Park S, Lee WH, J. Ind. Eng. Chem., 7(4), 230 (2001)

[Referenced By]

[Related Articles]

[1] Lee ARC, Tojo K, Chem. Pharm. Bull., 46, 174 (1998)

[2] Tojo K, Lee ARC, J. Soc. Cosmet. Chem., 38, 333 (1987)

[3] Kammerau B, Zesch A, Stuttgen G, J. Invest. Derm., 64, 145 (1975)

[4] Schaefer H, Zesch A, Stuttgen G, Arch. Derm. Res., 258, 241 (1977)

[5] Guy RH, Hadgraft J, in Models in Dermatology, Karger, Band 2, Basel, 170 (1985)

[6] Kakemi K, Kameda H, Ueda M, Koizumi T, Chem. Pharm. Bull., 23, 2109 (1975)

[7] Tojo K, Chem. Eng. Jpn., 20, 300 (1987)

[8] Tojo K, Lee ARC, J. Soc. Cosmet. Chem., 40, 119 (1989)

[9] Manitz R, Lucht W, Strehmel K, Weiner R, Neubert R, J. Pharm. Sci., 87, 873 (1998)

[10] Brown PN, Byrne GD, Hindmarsh AC, J. Sci. Stat. Comput., SIAM, 10, 1038 (1989)

[11] Choi JW, Cho KS, Oh BK, Youn IJ, Jeong J, Park S, Lee WH, J. Ind. Eng. Chem., 7(4), 230 (2001)