To improve the performance of multivariate statistical process control (MSPC), two advanced methods, moving principal component analysis (MPCA) and DISSIM. have been proposed. In MPCA and DISSIM, an abnormal operation can be detected by monitoring the directions of principal components and the dissimilarity index, respectively. Another important extension of MSPC was made with Multiscale PCA (MS-PCA). The present work investigates the characteristics of several statistical monitoring methods. The monitoring performance is compared with applications to simulated data obtained from a 2 x 2 process and the Tennessee Eastman process. The superiority of MPCA and DISSIM over the conventional methods comes from the fact that those methods focus on changes in the distribution of process data. Furthermore, the advantages of MPCA or DISSIM over the conventional MSPC and that of MS-PCA are combined, and new methods, termed MS-MPCA and MS-DISSIM, are proposed.