The isobaric vapor-liquid equilibria (VLE) for the binary systems 1,1,2,3,3,3-hexafluoropropyl, 2,2,2-trifluoroethyl ether (HFE-449mec-f), i.e. CF3CHFCF2OCH2CF3, + methanol, ethanol, 2-propanol or trans-1,2-dichloroethylene have been measured at 101.3 kPa. The measurements were made in an equilibrium still, developed in a previous study, with circulation of both the vapor and liquid phase. The four binary isobaric systems of the HFE-449mec-f with organic solvents exhibit minimum boiling azeotropes. The thermodynamic consistencies of the experimental data were good by the Van Ness and the Herington methods. The experimental data for the binary systems investigated were correlated with activity coefficient equations. The nonrandom two-liquid (NRTL) equation yielded a good correlation of activity coefficients.