The 65-node thermoregulation model was developed, based on the Stolwijk model. The model has 16 body segments corresponding to the thermal manikin, each consisting of four layers for core, muscle, fat and skin. The 65th node in the model is the central blood compartment, which exchanges convective heat with all other nodes via the blood flow. Convective and radiant heat transfer coefficients and clothing insulation were derived from the thermal manikin experiments. A thermoregulation model combined with radiation exchange model and computational fluid dynamics (CFD) is proposed. The comprehensive simulation method is described.