The medium-range production scheduling problem of a multiproduct batch plant is studied. The methodology consists of a decomposition of the whole scheduling period to successive short horizons. A mathematical model is proposed to determine each short horizon and the products to be included. Then a novel continuous-time formulation for short-term scheduling of batch processes with multiple intermediate due dates is applied to cacti time horizon selected, leading to a large-scale mixed-integer linear programming (MILP) problem. Special structures of the problem are further exploited to improve the computational performance. An integrated graphical user interface implementing the proposed optimization framework is presented. The effectiveness of the proposed approach is illustrated with a large-scale industrial case study that features the production of 35 different products according to a basic three-stage recipe and its variations by sharing 10 pieces of equipment.