The interfacial instabilities important to the modeling of critical heat flux (CHF) in reduced-gravity systems are sensitive to even minute body forces, especially for small coolant velocities, Understanding these effects is of paramount importance to both the reliability and safety of two-phase thermal management loops proposed for future space and planetary-based thermal systems. Unfortunately, reduced gravity systems cannot be accurately simulated in Ig ground-based experiments. However, ground-based experiments can help isolate the effects of the various forces (body force, surface tension force and inertia) which influence flow boiling CHF. In this project, the effects of the component of body force perpendicular to a heated wall were examined by conducting Ig flow boiling experiments at different orientations. Boiling experiments were performed using FC-72 in vertical and inclined upflow and downflow, as well as horizontal flow, and with the heated surface facing upward or downward relative to gravity. CHF was very sensitive to orientation for flow velocities below 0.2 m/s and near-saturated flow; CHF values for downflow and downward-facing heated surface were much smaller than for upflow and upward-facing surface orientations, Increasing velocity and subcooling dampened the effects of flow orientation on CHF. For saturated flow, the vapor layer characteristics fell into six different regimes: wavy vapor layer, pool-boiling, stratification, vapor stagnation, vapor counterflow, and vapor concurrent flow. The wavy vapor layer regime encompassed all subcooled and high-velocity saturated conditions at all orientations, as well as low-velocity upflow orientations. Prior CHF correlations and models were compared, and shown to predict the CHF data with varying degrees of success.