While deep hydrodesulfurization of gas oil is more and more important, elimination of sulfur compounds such as 4,6-dialkyldibenzothiophenes still attracts considerable attention. A new process based on the association of a separation process by charge-transfer complex (CTC) formation and classical catalytic hydrotreating (HDT) was evaluated. The results indicated that a CTC pretreatment allows the rate of hydrodesulfurization (HDS) to increase and the final sulfur level to decrease. This process is even more efficient for feeds difficult to desulfurize.