The industrial catalytic-distillation process for the production of methyl tert-butyl ether (MTBE) from methanol and isobutylene was simulated by developing the process model as a user modular on Aspen plus platform. The model utilizes the Aspen plus system and retains the characteristics of the self-designed model, which has been verified in various scale-up processes. The experimentally determined reaction kinetics was applied in the model. NRTL and Redlick-Kwong-Soave equations were selected for the vapor-liquid equilibrium calculation. The NRTL binary interaction parameters were estimated from the experimental data of the two-component vapor-liquid equilibrium. Two typical industrial plants for the MTBE production, one using the loose-stack-type package technology and the other using the bale-type package technology in the catalytic-distillation column, were chosen as the sample processes to demonstrate the validity of the model. The flowsheet simulations of the two industrial plants were done on Aspen plus platform, in which the simulation of the catalytic-distillation column used the developed user modular. The results show that fair agreements between the calculated and operating data were obtained.