The main barrier for end-use energy efficiency and renewable energy in the Czech Republic is the lack of a stable political and regulatory framework. Market incentives can only properly work if the market conditions and restrictions are clear and stable. However, no comprehensive policies and regulation have been implemented in the Czech Republic. Although the acquis communautaire of the European Union includes regulation on energy efficiency and renewable energy, this topic remains low on the negotiation agenda for accession. This paper reports on the current situation in the Czech Republic, including the potentials for end-use energy efficiency and renewable energy, on the existing policy and regulatory framework, and on the remaining gaps with the requirements of accession to the European Union. Also, the impact of the recent increase of nuclear capacity on energy efficiency and renewable energy in the Czech Republic is discussed.