N-oxide polymers possess strong zwitterionic character, high solubility in water, and high chelating properties with various cations. In this work, N-oxide polymers were synthesized following various routes and their solution properties were determined. Molecular properties of the polymers (molecular weight, square root of the meansquared radius, and virial coefficients) were related to their chain expansion in solution by determining the intrinsic viscosity as a function of pH. Viscosity results were correlated with the flocculation ability of the polymers for suspending solids removal. These polymers exhibit dramatic conformation changes as the solution pH is varied, especially at low pH values.