In this paper, a systematic method is proposed for the design of general multivariable controller for complex processes to achieve the goal of fast loop responses with acceptable overshoots and minimum loop interaction while maintaining low complexity of the feedback controller. The design of general transfer function type controller is based on the fundamental relations under decoupling of a multivariable, process, and the characterization of the unavoidable time delays and non-minimum phase zeros that are inherent in the decoupled loops. The objective loop transfer functions are then suitably specified to achieve fast loop response taking into account the performance limitation imposed by those non-minimum phase zeros and time delays. The ideal controller is then obtained which is in general a complicated irrational transfer matrix, for which model reduction with recursive least squares is applied in the frequency domain to obtain a much simpler transfer matrix with its elements in the form of rational transfer function plus delay. Simulations show that very satisfactory control performance is achieved. (C) 2003 Elsevier Science Ltd. All rights reserved.