Poly(acrylate-co-vinylacetate) Adhesive Patch for Sustained Dermal Delivery of Vitamin A

Yoon Sung Nam; Ju Won Kim; Sang-Hoon Han; Ih-Seop Chang

Journal of Industrial and Engineering Chemistry, Vol.9, No.2, 153-158, March, 2003

Export Citation

Poly(acrylate-co-vinylacetate) Adhesive Patch for Sustained Dermal Delivery of Vitamin A

Yoon Sung Nam^†, Ju Won Kim, Sang-Hoon Han, and Ih-Seop Chang

Amore Pacific R&D Center, Gyounggi-do 449-729, Korea

E-mail:

An adhesive patch-type delivery system is suggested for sustained dermal application of vitamin A. Poly(acrylate-co-vinylacetate) was used as a pressure-sensitive adhesive. In vivo skin permeation of vitamin A from the patch was studied and compared with that of a conventional oil-in-water cream. The patch was found to enable to prolong the skin permeation of vitamin A, whereas the cream showed an initial burst skin absorption. The relative vitamin A bioavailability of the patch was about 76.9%, compared with that of the cream. Patches were less irritable to skin than the cream when the same amount of vitamin A was loaded. The lower skin irritancy might be due to the sustained release of vitamin A from the patch matrix. Silicon replica analysis was carried out as a clinical study to quantify the effects of the vitamin A patch on cutaneous relief. Repeated application of vitamin A-loaded patches onto crow's feet wrinkles for 12 weeks resulted in a reduction of the total surface area and the length of the wrinkles by up to 23% and 17%, respectively, without irritation.

Keywords:patch;vitamin A;dermal delivery;sustained release;skin irritation

[References]

Fox C, Cosmet. Toilet., 112, 67 (1997)
Zatz JL, Cosmet. Toilet., 115, 31 (2000)
Kim SY, Lee YM, J. Ind. Eng. Chem., 5(4), 306 (1999)
Wiechers JW, Cosmet. Toilet., 115, 39 (2000)
Joung WD, Yi SC, J. Ind. Eng. Chem., 8(2), 191 (2002)
Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ, J. Invest. Dermatol., 114, 480 (2000)
Klingman LH, Gans EH, J. Dermatol. Treat., 11, 47 (2000)
Peck GL, DiGiovanna JJ, The Retinoids: Biology, Chemistry, and Medicine, 2nd ed., M.B. Sporn, A.B. Roberts, and D.S. Goodman, Eds., Raven Press, New York, pp. 631-658 (1994)
Orfanos CE, Zouboulis CC, Almond-Roesler B, Gelien CC, Drugs, 53, 358 (1997)
Leyden J, J. Am. Acad. Dermatol., 38, S1 (1998)
Fluhr JW, Vienne MP, Lauze C, Dupuy P, Gehring W, Gloor M, Dermatology, 199, 57 (1999)
Jenning V, Schaefer-Korting M, Gohla S, J. Control. Release, 66, 115 (2000)
Jenning V, Gysler A, Schaefer-Korting M, Gohla S, Eur. J. Pharm. Biopharm., 49, 211 (2000)
Rossler B, Kreuter J, Ross G, Pharmazie, 49, 175 (1994)
Tsunoda T, Takabayashi K, J. Soc. Cosmet. Chem., 46, 191 (1995)
Embil K, Nacht S, J. Microencapsul., 13(5), 575 (1996)
Montenegro L, Panico AM, Ventimiglia A, Bonina FP, Int. J. Pharm., 133, 89 (1996)
Schreier H, Bouwstra J, J. Control. Release, 30, 1 (1994)
Tse MF, McElrath KO, Adhes. Age, 36 (1988)
Satas D, Adhes. Age, 28 (1988)
Maillard-Salin DG, Becourt P, Couarraze G, Int. J. Pharm., 200, 121 (2000)
Torrado S, Torrado JJ, Cadorniga R, Int. J. Pharm., 86, 147 (1992)
Corcuff P, Chatenay F, Brun A, Int. J. Cosmet. Sci., 7, 117 (1985)
Leveque JL, Corcuff P, The Surface of the Skin the Microrelief, P.J. Frosch and A.M. Klingman, Eds., Springer-Verlag, Berlin, New York, Paris, pp. 3-24 (1993)
Peel Adhesion of Single Coated Pressure Sensitive Tapes at 180° angle in Test Methods for Pressure Sensitive Tapes, 10th Ed., Pressure Sensitive Tape Council, Chicago, p. 23-24 (1992)
CTFA Safety Testing Guideline, The Cosmetic, Toiletry, and Fragrance Association, Inc., Washington D.C., p. 1-4 (1981)

[1] Fox C, Cosmet. Toilet., 112, 67 (1997)

[2] Zatz JL, Cosmet. Toilet., 115, 31 (2000)

[3] Kim SY, Lee YM, J. Ind. Eng. Chem., 5(4), 306 (1999)

[4] Wiechers JW, Cosmet. Toilet., 115, 39 (2000)

[5] Joung WD, Yi SC, J. Ind. Eng. Chem., 8(2), 191 (2002)

[6] Varani J, Warner RL, Gharaee-Kermani M, Phan SH, Kang S, Chung JH, Wang ZQ, Datta SC, Fisher GJ, Voorhees JJ, J. Invest. Dermatol., 114, 480 (2000)

[7] Klingman LH, Gans EH, J. Dermatol. Treat., 11, 47 (2000)

[8] Peck GL, DiGiovanna JJ, The Retinoids: Biology, Chemistry, and Medicine, 2nd ed., M.B. Sporn, A.B. Roberts, and D.S. Goodman, Eds., Raven Press, New York, pp. 631-658 (1994)

[9] Orfanos CE, Zouboulis CC, Almond-Roesler B, Gelien CC, Drugs, 53, 358 (1997)

[10] Leyden J, J. Am. Acad. Dermatol., 38, S1 (1998)

[11] Fluhr JW, Vienne MP, Lauze C, Dupuy P, Gehring W, Gloor M, Dermatology, 199, 57 (1999)

[12] Jenning V, Schaefer-Korting M, Gohla S, J. Control. Release, 66, 115 (2000)

[13] Jenning V, Gysler A, Schaefer-Korting M, Gohla S, Eur. J. Pharm. Biopharm., 49, 211 (2000)

[14] Rossler B, Kreuter J, Ross G, Pharmazie, 49, 175 (1994)

[15] Tsunoda T, Takabayashi K, J. Soc. Cosmet. Chem., 46, 191 (1995)

[16] Embil K, Nacht S, J. Microencapsul., 13(5), 575 (1996)

[17] Montenegro L, Panico AM, Ventimiglia A, Bonina FP, Int. J. Pharm., 133, 89 (1996)

[18] Schreier H, Bouwstra J, J. Control. Release, 30, 1 (1994)

[19] Tse MF, McElrath KO, Adhes. Age, 36 (1988)

[20] Satas D, Adhes. Age, 28 (1988)

[21] Maillard-Salin DG, Becourt P, Couarraze G, Int. J. Pharm., 200, 121 (2000)

[22] Torrado S, Torrado JJ, Cadorniga R, Int. J. Pharm., 86, 147 (1992)

[23] Corcuff P, Chatenay F, Brun A, Int. J. Cosmet. Sci., 7, 117 (1985)

[24] Leveque JL, Corcuff P, The Surface of the Skin the Microrelief, P.J. Frosch and A.M. Klingman, Eds., Springer-Verlag, Berlin, New York, Paris, pp. 3-24 (1993)

[25] Peel Adhesion of Single Coated Pressure Sensitive Tapes at 180° angle in Test Methods for Pressure Sensitive Tapes, 10th Ed., Pressure Sensitive Tape Council, Chicago, p. 23-24 (1992)

[26] CTFA Safety Testing Guideline, The Cosmetic, Toiletry, and Fragrance Association, Inc., Washington D.C., p. 1-4 (1981)